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Issue 13, 2015
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The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication

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Abstract

Hyaluronic acid solutions have been widely studied due to their relevance to the rheological behavior of synovial fluid and joint lubrication. Ambulatory joint motion is typically large oscillatory deflections; therefore, large amplitude oscillatory shear strain experiments are used to examine the relevant non-linear viscoelastic properties of these solutions. Using the sequence of physical processes method to analyze data provides time dependent viscoelastic moduli, which exhibit a clear physiologically relevant behavior to hyaluronic acids non-linear viscoelasticity. In particular, it is seen that during peak strain/acceleration, the time dependent elastic modulus peaks and the loss modulus is at a minimum. The hyaluronic acid can provide an immediate elastic response to sudden forces, acting like a shock absorber during sudden changes in direction of motion or maximum deflection. However, during peak rate, the elastic modulus is at a minimum and the loss modulus is at a maximum, which provides greater efficacy to hydrodynamic shear lubrication.

Graphical abstract: The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication

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Publication details

The article was received on 16 Jan 2015, accepted on 09 Feb 2015 and first published on 09 Feb 2015


Article type: Paper
DOI: 10.1039/C5SM00131E
Citation: Soft Matter, 2015,11, 2596-2603
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    The nonlinear viscoelasticity of hyaluronic acid and its role in joint lubrication

    Z. Zhang and G. F. Christopher, Soft Matter, 2015, 11, 2596
    DOI: 10.1039/C5SM00131E

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