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Issue 2, 2015
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Examining platelet adhesion via Stokes flow simulations and microfluidic experiments

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Abstract

While critically important, the platelet function at the high shear rates typical of the microcirculation is relatively poorly understood. Using a large scale Stokes flow simulation, Zhao et al. recently showed that RBC-induced velocity fluctuations cause platelets to marginate into the RBC free near-wall region [Zhao et al., Physics of Fluids, 2012, 24, 011902]. We extend their work by investigating the dynamics of platelets in shear after margination. An overall platelet adhesion model is proposed in terms of a continuous time Markov process and the transition rates are established with numerical simulations involving platelet–wall adhesion. Hydrodynamic drag and Brownian forces are calculated with the boundary element method, while the RBC collisions are incorporated through an autoregressive process. Hookean springs with first order bond kinetics are used to model receptor–ligand bonds formed between the platelet and the wall. The simulations are compared with in vitro microfluidic experiments involving platelet adhesion to Von Willebrand Factor (VWF) coated surfaces.

Graphical abstract: Examining platelet adhesion via Stokes flow simulations and microfluidic experiments

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Publication details

The article was received on 03 Jul 2014, accepted on 29 Sep 2014 and first published on 10 Nov 2014


Article type: Paper
DOI: 10.1039/C4SM01450B
Author version available: Download Author version (PDF)
Citation: Soft Matter, 2015,11, 355-367
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    Examining platelet adhesion via Stokes flow simulations and microfluidic experiments

    S. Fitzgibbon, J. Cowman, A. J. Ricco, D. Kenny and E. S. G. Shaqfeh, Soft Matter, 2015, 11, 355
    DOI: 10.1039/C4SM01450B

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