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Issue 5, 2015
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Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion

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Abstract

An iron-catalyzed enantioselective and diastereoselective intramolecular olefin aminochlorination reaction is reported (ee up to 92%, dr up to 15 : 1). In this reaction, a functionalized hydroxylamine and chloride ion are utilized as nitrogen and chlorine sources, respectively. This new method tolerates a range of synthetically valuable internal olefins that are all incompatible with existing asymmetric olefin aminochlorination methods.

Graphical abstract: Iron(ii)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion

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Publication details

The article was received on 20 Jan 2015, accepted on 13 Mar 2015 and first published on 13 Mar 2015


Article type: Edge Article
DOI: 10.1039/C5SC00221D
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Citation: Chem. Sci., 2015,6, 3044-3050
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    Iron(II)-catalyzed asymmetric intramolecular olefin aminochlorination using chloride ion

    C. Zhu, J. Tian, Z. Gu, G. Xing and H. Xu, Chem. Sci., 2015, 6, 3044
    DOI: 10.1039/C5SC00221D

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