Issue 4, 2015

Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

Abstract

Many metal ions are present in biology and in the human body in trace amounts. Despite numerous efforts, metal sensors with ultrahigh sensitivity (<a few picomolar) are rarely achieved. Here, we describe a platform method that integrates a Cu2+-dependent DNAzyme into graphene–molecule junctions and its application for direct detection of paramagnetic Cu2+ with femtomolar sensitivity and high selectivity. Since DNAzymes specific for other metal ions can be obtained through in vitro selection, the method demonstrated here can be applied to the detection of a broad range of other metal ions.

Graphical abstract: Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

Supplementary files

Article information

Article type
Edge Article
Submitted
21 Nov 2014
Accepted
04 Feb 2015
First published
05 Feb 2015
This article is Open Access

All publication charges for this article have been paid for by the Royal Society of Chemistry
Creative Commons BY license

Chem. Sci., 2015,6, 2469-2473

Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

L. Gao, L. Li, X. Wang, P. Wu, Y. Cao, B. Liang, X. Li, Y. Lin, Y. Lu and X. Guo, Chem. Sci., 2015, 6, 2469 DOI: 10.1039/C4SC03612C

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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