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Issue 1, 2015
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A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

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Abstract

Agents enabling tumor staging are valuable for cancer surgery. Herein, a targetable sialic acid-armed near-infrared profluorophore (SA-pNIR) is reported for fluorescence guided tumor detection. SA-pNIR consists of a sialic acid entity effective for in vivo tumor targeting and a profluorophore which undergoes lysosomal acidity-triggered fluorogenic isomerization. SA-pNIR displays a number of advantageous biomedical properties in mice, e.g. high tumor-to-normal tissue signal contrast, long-term retention in tumors and low systemic toxicity. In addition, SA-pNIR effectively converts NIR light into cytotoxic heat in cells, suggesting tumor-activatable photothermal therapy. With high performance tumor illumination and lysosome-activatable photothermal properties, SA-pNIR is a promising agent for detection and photothermal ablation of surgically exposed tumors.

Graphical abstract: A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

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Publication details

The article was received on 28 Jul 2014, accepted on 19 Sep 2014 and first published on 25 Sep 2014


Article type: Edge Article
DOI: 10.1039/C4SC02248C
Citation: Chem. Sci., 2015,6, 798-803
  • Open access: Creative Commons BY license
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    A sialic acid-targeted near-infrared theranostic for signal activation based intraoperative tumor ablation

    X. Wu, M. Yu, B. Lin, H. Xing, J. Han and S. Han, Chem. Sci., 2015, 6, 798
    DOI: 10.1039/C4SC02248C

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