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Issue 9, 2015
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Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

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Abstract

Taddol-based phosphoramidite ligands enable enantioselective palladium(0)-catalyzed C–H arylation of cyclopropanes. The cyclized products are obtained in high yields and enantioselectivities. The reported method provides efficient access to a broad range of synthetically attractive cyclopropyl containing dihydroquinolones and dihydroisoquinolones as well as allows for an efficient enantioselective construction of the 7-membered ring of the cyclopropyl indolobenzazepine core of BMS-791325.

Graphical abstract: Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

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Publication details

The article was received on 27 May 2015, accepted on 17 Jun 2015 and first published on 17 Jun 2015


Article type: Edge Article
DOI: 10.1039/C5SC01909E
Citation: Chem. Sci., 2015,6, 5164-5171
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    Enantioselective palladium(0)-catalyzed intramolecular cyclopropane functionalization: access to dihydroquinolones, dihydroisoquinolones and the BMS-791325 ring system

    J. Pedroni, T. Saget, P. A. Donets and N. Cramer, Chem. Sci., 2015, 6, 5164
    DOI: 10.1039/C5SC01909E

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