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Issue 6, 2015
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Controlling the activity of quorum sensing autoinducers with light

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Abstract

Bacteria use a communication system, called quorum sensing (QS), to organize into communities and synchronize gene expression to promote virulence and secure survival. Here we report on a proof-of-principle for externally interfering with this bacterial communication system, using light. By employing photoswitchable small molecules, we were able to photocontrol the QS-related bioluminescence in an Escherichia coli reporter strain, and the expression of target QS genes and pyocyanin production in Pseudomonas aeruginosa.

Graphical abstract: Controlling the activity of quorum sensing autoinducers with light

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Publication details

The article was received on 20 Jan 2015, accepted on 25 Apr 2015 and first published on 27 Apr 2015


Article type: Edge Article
DOI: 10.1039/C5SC00215J
Citation: Chem. Sci., 2015,6, 3593-3598
  • Open access: Creative Commons BY license
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    Controlling the activity of quorum sensing autoinducers with light

    J. P. Van der Berg, W. A. Velema, W. Szymanski, A. J. M. Driessen and B. L. Feringa, Chem. Sci., 2015, 6, 3593
    DOI: 10.1039/C5SC00215J

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