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Issue 3, 2015
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A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

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Abstract

Activatable molecular systems enabling precise tumor localization are valuable for complete tumor resection. Herein, we report sialic acid-capped polymeric nanovesicles encapsulating the near infrared profluorophore (pNIR@P@SA) for lysosome activation based dual modality tumor imaging. The probe features surface-anchored sialic acid for tumor targeting and a core of near infrared profluorophore (pNIR) which undergoes lysosomal acidity triggered isomerization to give optical and optoacoustic signals upon cell internalization. Imaging studies reveal high-efficiency uptake and signal activation of pNIR@P@SA in subcutaneous tumors and millimeter-sized liver tumor foci in mice. The high tumor-to-healthy organ signal contrasts and discernment of tiny liver tumors from normal liver tissues validate the potential of pNIR@P@SA for high performance optical and optoacoustic imaging guided tumor resection.

Graphical abstract: A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

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Publication details

The article was received on 24 Nov 2014, accepted on 22 Dec 2014 and first published on 22 Dec 2014


Article type: Edge Article
DOI: 10.1039/C4SC03641G
Citation: Chem. Sci., 2015,6, 2002-2009
  • Open access: Creative Commons BY license
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    A carbohydrate-grafted nanovesicle with activatable optical and acoustic contrasts for dual modality high performance tumor imaging

    X. Wu, B. Lin, M. Yu, L. Yang, J. Han and S. Han, Chem. Sci., 2015, 6, 2002
    DOI: 10.1039/C4SC03641G

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