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Issue 4, 2015
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Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

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Abstract

Many metal ions are present in biology and in the human body in trace amounts. Despite numerous efforts, metal sensors with ultrahigh sensitivity (<a few picomolar) are rarely achieved. Here, we describe a platform method that integrates a Cu2+-dependent DNAzyme into graphene–molecule junctions and its application for direct detection of paramagnetic Cu2+ with femtomolar sensitivity and high selectivity. Since DNAzymes specific for other metal ions can be obtained through in vitro selection, the method demonstrated here can be applied to the detection of a broad range of other metal ions.

Graphical abstract: Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

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Publication details

The article was received on 21 Nov 2014, accepted on 04 Feb 2015 and first published on 05 Feb 2015


Article type: Edge Article
DOI: 10.1039/C4SC03612C
Citation: Chem. Sci., 2015,6, 2469-2473
  • Open access: Creative Commons BY license
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    Graphene–DNAzyme junctions: a platform for direct metal ion detection with ultrahigh sensitivity

    L. Gao, L. Li, X. Wang, P. Wu, Y. Cao, B. Liang, X. Li, Y. Lin, Y. Lu and X. Guo, Chem. Sci., 2015, 6, 2469
    DOI: 10.1039/C4SC03612C

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