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Issue 2, 2015
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A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

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Abstract

A configurable platform for synthetic chemistry incorporating an in-line benchtop NMR that is capable of monitoring and controlling organic reactions in real-time is presented. The platform is controlled via a modular LabView software control system for the hardware, NMR, data analysis and feedback optimization. Using this platform we report the real-time advanced structural characterization of reaction mixtures, including 19F, 13C, DEPT, 2D NMR spectroscopy (COSY, HSQC and 19F-COSY) for the first time. Finally, the potential of this technique is demonstrated through the optimization of a catalytic organic reaction in real-time, showing its applicability to self-optimizing systems using criteria such as stereoselectivity, multi-nuclear measurements or 2D correlations.

Graphical abstract: A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

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Publication details

The article was received on 08 Oct 2014, accepted on 14 Nov 2014 and first published on 14 Nov 2014


Article type: Edge Article
DOI: 10.1039/C4SC03075C
Citation: Chem. Sci., 2015,6, 1258-1264
  • Open access: Creative Commons BY-NC license
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    A self optimizing synthetic organic reactor system using real-time in-line NMR spectroscopy

    V. Sans, L. Porwol, V. Dragone and L. Cronin, Chem. Sci., 2015, 6, 1258
    DOI: 10.1039/C4SC03075C

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