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Issue 113, 2015
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The urea cycle of rat white adipose tissue

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Abstract

White adipose tissue (WAT) contains a powerful metabolic machinery related to energy metabolism and partition. The adaptive, regulatory, size and structural variety of WAT agrees with this control role. However, its nitrogen metabolism has been sparsely studied and we know close to nothing about its implication on N-related processes and homoeostasis. We have studied, and found a complete urea cycle (liver type) in four WAT sites (gene expressions and enzyme activities). We postulated a possible function of the cycle (under basal conditions) in the control of arginine handling through citrulline synthesis. In our opinion, the metabolic and control potential of WAT on energy metabolism may be second only to liver. This impression should be extended to amino acid metabolism too, WAT providing an extra-intestinal source of citrulline to maintain the body availability of arginine independently of the operation of intestine–liver urea cycle for N disposal.

Graphical abstract: The urea cycle of rat white adipose tissue

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Publication details

The article was received on 14 Aug 2015, accepted on 19 Oct 2015 and first published on 19 Oct 2015


Article type: Paper
DOI: 10.1039/C5RA16398F
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Citation: RSC Adv., 2015,5, 93403-93414
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    The urea cycle of rat white adipose tissue

    S. Arriarán, S. Agnelli, X. Remesar, J. Fernández-López and M. Alemany, RSC Adv., 2015, 5, 93403
    DOI: 10.1039/C5RA16398F

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