Synthesis of isatins from formyl-N-arylformamides is achieved via PdCl2-catalyzed intramolecular acylation. This method shows the possibility of Pd-catalyzed aryl C(sp2)–H bond activation on the synthesis of isatins, affording an array of isatins in good yields. Yet this protocol is operationally simple and atom economical.
The article was received on 11 Nov 2015, accepted on 16 Nov 2015 and first published on 27 Nov 2015
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