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Issue 115, 2015
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Nanospheres from the self-assembly of an elastin-inspired triblock peptide

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Abstract

Peptide-based biomaterials are gaining increasing interest as biomaterials for tissue engineering as well as drug delivery systems. Many studies were conducted on amphiphilic or surfactant peptides, showing the great plethora of nanostructures that they can form, according to sequence and experimental conditions. In our work we were interested in the effect of secondary structure propensity of the peptide on the self-assembling properties. A designed peptide, having a conformation-based three-block structure, was able to form nanospheres of 100–400 nm diameter. The molecular and supramolecular structure was investigated by several biophysical techniques and highlights the important role of conformational flexibility and π–π stacking in the self-assembly of the peptide.

Graphical abstract: Nanospheres from the self-assembly of an elastin-inspired triblock peptide

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Publication details

The article was received on 12 Oct 2015, accepted on 29 Oct 2015 and first published on 29 Oct 2015


Article type: Paper
DOI: 10.1039/C5RA21182D
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 95007-95013
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    Nanospheres from the self-assembly of an elastin-inspired triblock peptide

    A. Scelsi, B. Bochicchio, A. Smith, A. Saiani and A. Pepe, RSC Adv., 2015, 5, 95007
    DOI: 10.1039/C5RA21182D

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