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Issue 126, 2015
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NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

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Abstract

A new NMR-based method to access to the unique components of the drug-like natural product metabolome of termite-gut associated actinomycetes has been developed. This approach was used to accelerate the identification of lead-like enhanced fractions containing small molecules with unique spectral patterns. The effectiveness of the approach was demonstrated by the isolation and identification of six new natural products, namely, actinoglycosidines A (1) and B (2), actinopolymorphol D (3), niveamycin A (7), B (8) and C (9).

Graphical abstract: NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

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Publication details

The article was received on 29 Aug 2015, accepted on 27 Nov 2015 and first published on 30 Nov 2015


Article type: Paper
DOI: 10.1039/C5RA17553D
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 104524-104534
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    NMR fingerprints, an integrated approach to uncover the unique components of the drug-like natural product metabolome of termite gut-associated Streptomyces species

    C. A. Romero, T. Grkovic, J. Han, L. Zhang, J. R. J. French, D. I. Kurtböke and R. J. Quinn, RSC Adv., 2015, 5, 104524
    DOI: 10.1039/C5RA17553D

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