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Issue 101, 2015
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Biocomposites for wound-healing based on sol–gel magnetite

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Abstract

Currently, efficient wound-healing materials are booming due to increasing health care costs and world population aging, but also because of a sharp increase in the incidence of diabetes and obesity. Exacting demands are placed upon modern wound-healing materials as these should affect all stages of healing by accelerating them. In this paper, we demonstrate for the first time that drug entrapped magnetite xerogels can be effectively used for this purpose. To prepare a healing biocomposite, we have combined four medicaments in a magnetite matrix: chlorhexidine digluconate as an antimicrobial agent, lidocaine as a painkiller, prednisolone as an anti-inflammatory agent and chymotrypsin as a necrolytic agent. Compared to the control group, the wound healing rate with a biocomposite exhibited a ∼1.5-fold increase (21 and 14 days for complete healing, respectively). Moreover application of a magnetite-based biocomposite provided strong scar size decrease. Characteristics of the magnetite matrix as well as wound-healing composite material are fully described by XRD, XPS, SEM, TEM and N2 physisorption analysis.

Graphical abstract: Biocomposites for wound-healing based on sol–gel magnetite

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Publication details

The article was received on 11 Aug 2015, accepted on 24 Sep 2015 and first published on 24 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA16177K
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 82992-82997
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    Biocomposites for wound-healing based on sol–gel magnetite

    A. S. Drozdov, K. V. Volodina, V. V. Vinogradov and V. V. Vinogradov, RSC Adv., 2015, 5, 82992
    DOI: 10.1039/C5RA16177K

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