Jump to main content
Jump to site search

Issue 100, 2015
Previous Article Next Article

Influence of carbon nanomaterial defects on the formation of protein corona

Author affiliations

Abstract

In any physiological media, carbon nanomaterials (CNM) strongly interact with biomolecules leading to the formation of biocorona, which subsequently dictate the physiological response and the fate of CNMs. Defects in CNMs play an important role not only in material properties but also in the determination of how materials interact at the nano-bio interface. In this article, we probed the influence of defect-induced hydrophilicity on the biocorona formation using micro-Raman, photoluminescence, infrared spectroscopy, electrochemistry, and molecular dynamics simulations. Our results show that the interaction of proteins (albumin and fibrinogen) with CNMs is strongly influenced by charge-transfer between them, inducing protein unfolding which enhances conformational entropy and higher protein adsorption.

Graphical abstract: Influence of carbon nanomaterial defects on the formation of protein corona

Back to tab navigation

Supplementary files

Publication details

The article was received on 28 Jul 2015, accepted on 23 Sep 2015 and first published on 23 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA15007H
Citation: RSC Adv., 2015,5, 82395-82402
  •   Request permissions

    Influence of carbon nanomaterial defects on the formation of protein corona

    B. Sengupta, W. E. Gregory, J. Zhu, S. Dasetty, M. Karakaya, J. M. Brown, A. M. Rao, J. K. Barrows, S. Sarupria and R. Podila, RSC Adv., 2015, 5, 82395
    DOI: 10.1039/C5RA15007H

Search articles by author

Spotlight

Advertisements