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Issue 95, 2015
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Liposome collapse resulting from an allosteric interaction between 2,6-dimethyl-β-cyclodextrins and lipids

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Abstract

Although heptakis(2,6-di-O-methyl)-β-cyclodextrin (DMe-β-CDx) has been reported to exhibit higher cytotoxicity than many other cyclodextrins because of the way in which it abstracts cholesterols from liposomes, we have identified another reason for its cytotoxicity based on its interaction with lipids. These interactions exhibited nonlinear sigmoidal responses with Hill coefficient values (n) in the range of 3.0–3.6, which indicated that this phenomenon involves positive allosterism. Furthermore, analysis by mass spectroscopy revealed that the lipid–DMe-β-CDx complexes had stoichiometric ratios in the range of 1 : 1–1 : 4.

Graphical abstract: Liposome collapse resulting from an allosteric interaction between 2,6-dimethyl-β-cyclodextrins and lipids

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Publication details

The article was received on 28 Jul 2015, accepted on 09 Sep 2015 and first published on 09 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA14970C
Citation: RSC Adv., 2015,5, 77746-77754
  • Open access: Creative Commons BY license
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    Liposome collapse resulting from an allosteric interaction between 2,6-dimethyl-β-cyclodextrins and lipids

    A. Ikeda, N. Iwata, S. Hino, T. Mae, Y. Tsuchiya, K. Sugikawa, T. Hirao, T. Haino, K. Ohara and K. Yamaguchi, RSC Adv., 2015, 5, 77746
    DOI: 10.1039/C5RA14970C

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