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Issue 107, 2015
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Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

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Abstract

Biocompatible multi-layer iron oxide magnetic nanoparticles (MNPs) for drug delivery applications with increased loading capacity, sustained sensitive release profile, and high inherent magnetic properties as well as improved cellular uptake were prepared. In this approach, Fe3O4 MNPs were obtained by a co-precipitation method and functionalized using hydroxyapatite (HAP) and/or polyethyleneimine (PEI). They were then modified with β-cyclodextrin (CD) to increase their loading capacity. These MNPs allowed suitable encapsulation of hydrophobic curcumin (CUR) in the CD shell and CUR adsorption into the polymeric layers. The dissolution profile of CUR showed pH sensitive release of CUR. The protein corona pattern of the MNPs by electrophoresis showed lower protein adsorption for CD modified MNPs than for other MNPs. No significant toxicity was observed for the target MNPs, whereas the CUR loaded MNPs inhibited MCF-7 breast cancer cells more efficiently than free CUR. Moreover, the negligible hemolytic activity of the target MNPs showed their excellent haemocompatibility for cancer treatment. The preferential uptake of the drug by MCF-7 cells was observed for CUR loaded MNPs in comparison with free CUR using flow cytometric analysis. As a result, the designed and prepared MNPs can be considered to be a promising CUR delivery platform.

Graphical abstract: Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

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Publication details

The article was received on 14 Jul 2015, accepted on 24 Sep 2015 and first published on 30 Sep 2015


Article type: Paper
DOI: 10.1039/C5RA13838H
Citation: RSC Adv., 2015,5, 88096-88107
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    Evaluation of multilayer coated magnetic nanoparticles as biocompatible curcumin delivery platforms for breast cancer treatment

    M. Akrami, M. Khoobi, M. Khalilvand-Sedagheh, I. Haririan, A. Bahador, M. A. Faramarzi, S. Rezaei, H. A. Javar, F. Salehi, S. K. Ardestani and A. Shafiee, RSC Adv., 2015, 5, 88096
    DOI: 10.1039/C5RA13838H

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