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Issue 82, 2015
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Zinc induced polyelectrolyte coacervate bioadhesive and its transition to a self-healing hydrogel

Weina Wang,ab  Yisheng Xu,*a  Ang Li,a  Tao Li,a  Miaomiao Liu,a  Regine von Klitzing,b  Christopher K. Ober,c  A. Basak Kayitmazer,d  Li Lia  and  Xuhong Guo*ae 
Author affiliations

* Corresponding authors

a State Key Laboratory of Chemical Engineering, East China University of Science and Technology, Shanghai 200237, China
E-mail: yshxu@ecust.edu.cn, guoxuhong@ecust.edu.cn

b Stranski-Laboratorium für Physikalische und Theoretische Chemie, Technische Universität Berlin, Strasse des 17. Juni 124, D-10623 Berlin, Germany

c Department of Materials Science and Engineering, Cornell University, Ithaca, USA

d Chemistry Department, Bogazici University, Bebek, Istanbul 34342, Turkey

e Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region and Engineering Research Center of Materials-Oriented Chemical Engineering of Xinjiang Bingtuan, Shihezi University, Xinjiang 832000, China

Abstract

To mimic the underwater adhesion of marine mussels, a bioadhesive has been prepared with a poly(acrylic acid) backbone functionalized with 30% catechol appendants. The polyelectrolyte chains can be reversibly crosslinked through metal chelation and irreversibly gelled by oxidative crosslinking. Surprisingly, the reported “poor” metal chelator Zn2+ not only imparts this injectable adhesive with superior adhesion after the formation of coacervation compared to the one chelated by a stronger metal crosslinker (e.g. Fe3+), but also generates good mechanical performance of the self-healing hydrogel after the oxidation of catechol groups with a pH trigger. Such a pH-responsive material with strong adhesion and good self-healing property at different conditions could be an ideal candidate in biomedical adhesion and tissue engineering.

Graphical abstract: Zinc induced polyelectrolyte coacervate bioadhesive and its transition to a self-healing hydrogel

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Publication details

The article was received on 23 Jun 2015, accepted on 30 Jul 2015 and first published on 30 Jul 2015


Article type: Paper
DOI: 10.1039/C5RA11915D
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 66871-66878
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    Zinc induced polyelectrolyte coacervate bioadhesive and its transition to a self-healing hydrogel

    W. Wang, Y. Xu, A. Li, T. Li, M. Liu, R. von Klitzing, C. K. Ober, A. B. Kayitmazer, L. Li and X. Guo, RSC Adv., 2015, 5, 66871
    DOI: 10.1039/C5RA11915D

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