Issue 80, 2015

DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)–H bond for the synthesis of isoquinolines

Abstract

A DBU-promoted cascade functionalization of a C(sp3)–H bond adjacent to oxygen and a radical cyclization reaction of vinyl isocyanides were developed. The reaction was carried out without the use of any metal catalysts or photoredox catalysis, which provides easy access to multi-functionalized isoquinolines.

Graphical abstract: DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)–H bond for the synthesis of isoquinolines

Supplementary files

Article information

Article type
Communication
Submitted
16 Jun 2015
Accepted
13 Jul 2015
First published
13 Jul 2015

RSC Adv., 2015,5, 64961-64965

Author version available

DBU-promoted cyclization of vinyl isocyanides with ethers via the functionalization of a C(sp3)–H bond for the synthesis of isoquinolines

P. Qian, B. Du, J. Zhou, H. Mei, J. Han and Y. Pan, RSC Adv., 2015, 5, 64961 DOI: 10.1039/C5RA11530B

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