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Issue 80, 2015
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Solid phase synthesis of functionalized indazoles using triazenes – scope and limitations

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Abstract

Indazoles are important heterocycles as they are a substantial part in many drugs. In this study, we present a modular synthesis of highly substituted indazoles via a strategy on solid supports. The heterocyclic nitrogen atoms originate from diazonium salts, being cleaved from triazene containing resins. The scope and limitations of this process are explored, considering especially the competitive occurrence of triazines and the cleavage of hydrolyzed and traceless side products.

Graphical abstract: Solid phase synthesis of functionalized indazoles using triazenes – scope and limitations

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Publication details

The article was received on 23 May 2015, accepted on 16 Jul 2015 and first published on 16 Jul 2015


Article type: Communication
DOI: 10.1039/C5RA09705C
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 65540-65545
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    Solid phase synthesis of functionalized indazoles using triazenes – scope and limitations

    A. M. Garcia, N. Jung, C. Gil, M. Nieger and S. Bräse, RSC Adv., 2015, 5, 65540
    DOI: 10.1039/C5RA09705C

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