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Issue 73, 2015
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Multicomponent synthesis of novel hybrid PHQ-fatty acids

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Abstract

Multicomponent reactions as methods for green synthesis are important pathways for obtaining pharmacological compounds. In this work, an efficient synthesis of new fatty Hantzsch derivative compounds using a four-component reaction is described. We demonstrate for the first time a fatty acid polyhydroquinoline (hybrid PHQ-fatty acids) synthesis from renewable resources containing C16 and C18 saturated and unsaturated fatty chains, including the ricinoleic acid (12-hydroxy-9-cis-octadecenoic acid), the major constituent of castor oil. The experimental results demonstrate that the best value for charging the sulfamic acid was 20 mol% and that thirty new hybrid PHQ-fatty acids were synthesised in good yields.

Graphical abstract: Multicomponent synthesis of novel hybrid PHQ-fatty acids

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Publication details

The article was received on 20 May 2015, accepted on 02 Jul 2015 and first published on 02 Jul 2015


Article type: Paper
DOI: 10.1039/C5RA09433J
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 59638-59647
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    Multicomponent synthesis of novel hybrid PHQ-fatty acids

    H. D. Fontecha-Tarazona, R. C. Brinkerhoff, P. M. de Oliveira, S. B. Rosa, D. C. Flores, C. D. R. Montes D'Oca, D. Russowsky and M. G. Montes D'Oca, RSC Adv., 2015, 5, 59638
    DOI: 10.1039/C5RA09433J

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