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Issue 63, 2015
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‘On-water’ organic synthesis: a green, highly efficient, low cost and reusable catalyst system for biaryl synthesis under aerobic conditions at room temperature

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Abstract

A simple, greener, efficient, low cost and mild protocol has been developed for sucrose assisted palladium-catalyzed Suzuki reactions in water at room temperature under aerobic conditions. The results demonstrate that the sucrose played a crucial role making this protocol highly efficient. The PdCl2/sucrose/K2CO3/H2O system showed superb catalytic activity towards the Suzuki reaction of a wide range of aryl/heteroaryl halides with different substituted phenylboronic acids. This method offers an attractive alternative to the existing protocols since the reaction proceeds in aqueous media at room temperature with operational simplicity, shorter reaction time, cost-effectiveness and provides the products in high yields. The catalytic system is highly recyclable, allowing the reuse of the palladium catalyst in subsequent catalytic runs without significant loss of activity.

Graphical abstract: ‘On-water’ organic synthesis: a green, highly efficient, low cost and reusable catalyst system for biaryl synthesis under aerobic conditions at room temperature

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Publication details

The article was received on 20 May 2015, accepted on 02 Jun 2015 and first published on 02 Jun 2015


Article type: Communication
DOI: 10.1039/C5RA09102K
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Citation: RSC Adv., 2015,5, 50655-50659
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    ‘On-water’ organic synthesis: a green, highly efficient, low cost and reusable catalyst system for biaryl synthesis under aerobic conditions at room temperature

    B. Saikia, P. R. Boruah, A. A. Ali and D. Sarma, RSC Adv., 2015, 5, 50655
    DOI: 10.1039/C5RA09102K

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