Jump to main content
Jump to site search

Issue 49, 2015
Previous Article Next Article

An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine

Author affiliations

Abstract

A simple and highly efficient synthetic approach to enantiopure 2-alkyl substituted tetrahydroquinoline 1 skeleton from aldehydes as starting materials and its application to the total synthesis of (+)-angustureine 2 is described. Key transformations include proline catalyzed aminoxylation, Corey–Fuchs protocol, Sonogashira coupling and intramolecular Mitsunobu reactions.

Graphical abstract: An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine

Back to tab navigation

Supplementary files

Publication details

The article was received on 03 Apr 2015, accepted on 23 Apr 2015 and first published on 23 Apr 2015


Article type: Communication
DOI: 10.1039/C5RA05987A
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 38846-38850
  •   Request permissions

    An enantioselective approach to 2-alkyl substituted tetrahydroquinolines: total synthesis of (+)-angustureine

    Y. Garg, S. Gahalawat and S. K. Pandey, RSC Adv., 2015, 5, 38846
    DOI: 10.1039/C5RA05987A

Search articles by author

Spotlight

Advertisements