Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

Swastika Singh; Mohammad Saquib; Shyam Babu Singh; Mandavi Singh; Jagdamba Singh

doi:10.1039/C5RA02794B

Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

Swastika Singh,^a Mohammad Saquib,^a Shyam Babu Singh,^b Mandavi Singh^a and Jagdamba Singh*^a

Author affiliations

* Corresponding authors

^a Environmentally Benign Synthesis Lab, Department of Chemistry, University of Allahabad, Allahabad-211002, India
E-mail: dr.jdsau@gmail.com
Tel: +91 9415218507

^b Department of Chemistry, Government College, Ramchandrapur, India

Abstract

The development of a versatile new one pot, catalyst free, multicomponent-tandem strategy for assembly of spirooxindole-indazolones and spirooxindole-pyrazolines is described. The reported protocol includes several advantages like environmental friendliness, cost effectiveness, high atom economy, short reaction times and high yields. The reported method is the first green synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines.

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Publication details

The article was received on 12 Feb 2015, accepted on 08 May 2015 and first published on 08 May 2015

Article type: Paper

DOI: 10.1039/C5RA02794B

Citation: RSC Adv., 2015,5, 45152-45157

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Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

S. Singh, M. Saquib, S. B. Singh, M. Singh and J. Singh, RSC Adv., 2015, 5, 45152
DOI: 10.1039/C5RA02794B
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Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

Abstract

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Catalyst free, multicomponent-tandem synthesis of spirooxindole-indazolones and spirooxindole-pyrazolines: a glycerol mediated green approach

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