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Issue 45, 2015
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Gallic acid: prospects and molecular mechanisms of its anticancer activity

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Abstract

Cancer is the second leading cause of death worldwide. There is always a huge demand for novel anticancer drugs and scientists explore various natural and artificial compounds to overcome this. Gallic acid (GA) is one of the phenolic acids found in many dietary substances and herbs used in ancient medicine. It possesses antiinflammatory, antioxidant, antiviral and antibacterial properties. The present review summarizes the anticancer activity of GA and its derivatives. Various in vitro and in vivo experiments of GA against a variety of cancer cell lines were reported. The previous studies show that the anticancer activity of GA is related to the induction of apoptosis through different mechanisms like generation of reactive oxygen species (ROS), regulation of apoptotic and anti-apoptotic proteins, suppression and promotion of oncogenes, inhibition of matrix metalloproteinases (MMPs) and cell cycle arrest depending upon the type of cancer investigated. Conclusively, GA and its derivatives may be considered as a potent drug for cancer treatment alone as well as in combination with other anticancer drugs to increase the efficiency of chemotherapy. However, there is still a need for more experimentation in knock-out animal models and human clinical trials to promote and place GA and its derivatives on the commercial market.

Graphical abstract: Gallic acid: prospects and molecular mechanisms of its anticancer activity

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Publication details

The article was received on 12 Feb 2015, accepted on 27 Mar 2015 and first published on 27 Mar 2015


Article type: Review Article
DOI: 10.1039/C5RA02727F
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 35608-35621
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    Gallic acid: prospects and molecular mechanisms of its anticancer activity

    A. P. Subramanian, A. A. John, M. V. Vellayappan, A. Balaji, S. K. Jaganathan, E. Supriyanto and M. Yusof, RSC Adv., 2015, 5, 35608
    DOI: 10.1039/C5RA02727F

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