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Issue 32, 2015
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Synthesis and biological evaluation of novel 1,2-naphthoquinones possessing tetrazolo[1,5-a]pyrimidine scaffolds as potent antitumor agents

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Abstract

A series of novel 1,2-naphthoquinones possessing tetrazolo[1,5-a]pyrimidine scaffolds were synthesized in very good yields using one-pot condensation of 2-hydroxy-1,4-naphthoquinone, aldehydes, and 5-aminotetrazole. All the synthesized compounds were evaluated for their antitumor activity in vitro against HCT116 (human colon cancer) and HepG2 (human hepatoma) cell lines. Among the screened compounds, 4o, 4k, 4g, 4q, and 4s showed significant inhibitory activity against the two human cell lines.

Graphical abstract: Synthesis and biological evaluation of novel 1,2-naphthoquinones possessing tetrazolo[1,5-a]pyrimidine scaffolds as potent antitumor agents

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Publication details

The article was received on 13 Jan 2015, accepted on 03 Mar 2015 and first published on 03 Mar 2015


Article type: Paper
DOI: 10.1039/C5RA00711A
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Citation: RSC Adv., 2015,5, 24960-24965
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    Synthesis and biological evaluation of novel 1,2-naphthoquinones possessing tetrazolo[1,5-a]pyrimidine scaffolds as potent antitumor agents

    L. Wu, RSC Adv., 2015, 5, 24960
    DOI: 10.1039/C5RA00711A

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