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Issue 12, 2015
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Alginate–peptide amphiphile core–shell microparticles as a targeted drug delivery system

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Abstract

We describe in this work the synthesis of microparticles with a doxorubicin drug conjugated alginate core and a shell of peptide amphiphile nanofibres functionalized for targeting the folate receptor. The spherical geometry of the particle core allows high drug loading per surface area, whereas the nanoscale fibrous shell formed by self-assembly of peptide amphiphiles offers a high surface to volume ratio that is ideal for targeting. The synthesised microparticles have a 60-fold higher cytotoxicity against MDA-MB-231 breast cancer cells compared to non-targeting particles.

Graphical abstract: Alginate–peptide amphiphile core–shell microparticles as a targeted drug delivery system

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Publication details

The article was received on 09 Oct 2014, accepted on 19 Dec 2014 and first published on 08 Jan 2015


Article type: Communication
DOI: 10.1039/C4RA16593D
Citation: RSC Adv., 2015,5, 8753-8756
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    Alginate–peptide amphiphile core–shell microparticles as a targeted drug delivery system

    J. Boekhoven, R. H. Zha, F. Tantakitti, E. Zhuang, R. Zandi, C. J. Newcomb and S. I. Stupp, RSC Adv., 2015, 5, 8753
    DOI: 10.1039/C4RA16593D

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