Issue 18, 2015

The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications

Abstract

Five water-soluble cyclen-based europium complexes incorporated with the pendant chelating chromophore, 2-methyl-4-(2-(4-propoxyphenyl)ethynyl)pyridine (L), as the antenna in different ratios have been synthesized and full structural characterization, photophysical measurement and in vitro biological studies were carried out. The antenna-to-metal ratios were 4 (Eu-4L), 3 (Eu-3L), 2 (1,4-disubstituted Eu-o-2L and 1,7-disubstituted Eu-p-2L) and 1 (Eu-1L). It was found that the definitive distinction between Eu-o-2L and Eu-p-2L could be interpreted from the emission spectra of Eu3+ at room and low temperatures. With all the results from subcellular stability testing (via titrations), in vitro imaging, cytotoxicity assays and cellular uptake profiles, Eu-4L with an overall +3 charge demonstrated subcellular localization towards lysosomes and was a potential compound for a selective time-resolved bio-labelling probe.

Graphical abstract: The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications

Supplementary files

Article information

Article type
Paper
Submitted
17 Dec 2014
Accepted
13 Jan 2015
First published
13 Jan 2015

RSC Adv., 2015,5, 13347-13356

Author version available

The effects of the increasing number of the same chromophore on photosensitization of water-soluble cyclen-based europium complexes with potential for biological applications

Z. Liang, C. Chan, Y. Liu, W. Wong, C. Lee, G. Law and K. Wong, RSC Adv., 2015, 5, 13347 DOI: 10.1039/C4RA16536E

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