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Issue 45, 2015
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Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

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Abstract

Hydrogels based on poly(ethylene glycol) (PEG) and derivatives have attracted significant interest in recent years given their capacity to be well-tolerated in vivo in the context of drug delivery and tissue engineering applications. Injectable, in situ-gelling analogues of such hydrogels offer the additional advantages of being easy and non-invasive to administer via the injection of low-viscosity precursor polymer solutions, expanding their scope of potential applications. In this highlight, we first review the design criteria associated with the rational design of in situ-gelling hydrogels for in vivo applications. We then discuss recent progress in the design of injectable PEG hydrogels, specifically highlighting our ongoing work on PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) for targeted biomedical applications.

Graphical abstract: Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

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Publication details

The article was received on 01 Nov 2014, accepted on 10 Apr 2015 and first published on 13 Apr 2015


Article type: Review Article
DOI: 10.1039/C4RA13581D
Citation: RSC Adv., 2015,5, 35469-35486
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    Injectable hydrogels based on poly(ethylene glycol) and derivatives as functional biomaterials

    E. Bakaic, N. M. B. Smeets and T. Hoare, RSC Adv., 2015, 5, 35469
    DOI: 10.1039/C4RA13581D

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