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Issue 19, 2015
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Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

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Abstract

Single crystal X-ray studies of regioselectively synthesized fluoro-substituted dispiro-oxindole 9 revealed that the structure belongs to the monoclinic space group P21/n with four molecules in the unit cell. The structure was also investigated by AM1, PM3, and DFT studies. Compound 9 exhibits high potency against the HeLa cell line.

Graphical abstract: Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

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Publication details

The article was received on 29 Oct 2014, accepted on 13 Jan 2015 and first published on 13 Jan 2015


Article type: Communication
DOI: 10.1039/C4RA13433H
Citation: RSC Adv., 2015,5, 14780-14787
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    Regioselective synthesis and theoretical studies of an anti-neoplastic fluoro-substituted dispiro-oxindole

    A. S. Girgis, S. S. Panda, E. M. Shalaby, A. F. Mabied, P. J. Steel, C. D. Hall and A. R. Katritzky, RSC Adv., 2015, 5, 14780
    DOI: 10.1039/C4RA13433H

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