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Issue 3, 2015
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A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging

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Abstract

A novel reconstituted high-density lipoprotein (rHDL) nanocomposite has been prepared for highly-sensitive magnetic resonance (MR)-fluorescence multimodal imaging. Such a nanocomposite is able to enhance the MR sensitivity up to 129 fold in comparison to the traditional small molecule MRI agent based on paramagnetic chemical exchange saturation transfer (PARACEST). It has also demonstrated specific targeting to macrophage cells, which shows great potential for the detection of atherosclerosis.

Graphical abstract: A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging

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Publication details

The article was received on 11 Oct 2014, accepted on 28 Nov 2014 and first published on 28 Nov 2014


Article type: Communication
DOI: 10.1039/C4RA12201A
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Citation: RSC Adv., 2015,5, 1808-1811
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    A europium–lipoprotein nanocomposite for highly-sensitive MR-fluorescence multimodal imaging

    Q. Wang, S. Chen, Q. Luo, M. Liu and X. Zhou, RSC Adv., 2015, 5, 1808
    DOI: 10.1039/C4RA12201A

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