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Issue 10, 2015
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Surface charge effect on the cellular interaction and cytotoxicity of NaYF4:Yb3+, Er3+@SiO2 nanoparticles

Junping Zhang,ab  Fuyao Liu,bc  Tao Li,b  Xiuxia He*a  and  Zhenxin Wang*b 
Author affiliations

* Corresponding authors

a School of Life Science and Technology, Changchun University of Science and Technology, Changchun, China
E-mail: chinese_hxx@sohu.com

b State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, China
E-mail: wangzx@ciac.ac.cn

c University of Chinese Academy of Sciences, Beijing, China

Abstract

Taking advantage of the unique optical properties of upconversion nanoparticles (NP) and the feasibly modified nature of SiO2, NaYF4:Yb3+, Er3+@SiO2 core@shell (UCNP@SiO2) NPs with excellent morphology have been synthesized to investigate the surface charge effect on the interactions of NPs with cells. The cellular uptake behaviors, cytotoxicities and intracellular metal ion release of the as-prepared NPs have been investigated in two cell lines (HeLa and HepG-2) by fluorescence microscopy, MTT assay and inductively coupled plasma mass spectrometry (ICP-MS), respectively. It is found that the UCNP@SiO2 NPs with positive surface charge have much higher cell internalization ability and cytotoxicity than those with negative surface charge. The experimental results also demonstrate that the cytotoxicity of UCNP@SiO2 NP is closely related to the increase of intracellular reactive oxygen species (ROS) and metal ion release of internalized NPs.

Graphical abstract: Surface charge effect on the cellular interaction and cytotoxicity of NaYF4:Yb3+, Er3+@SiO2 nanoparticles

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Publication details

The article was received on 28 Sep 2014, accepted on 22 Dec 2014 and first published on 23 Dec 2014


Article type: Paper
DOI: 10.1039/C4RA11374H
Citation: RSC Adv., 2015,5, 7773-7780
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    Surface charge effect on the cellular interaction and cytotoxicity of NaYF4:Yb3+, Er3+@SiO2 nanoparticles

    J. Zhang, F. Liu, T. Li, X. He and Z. Wang, RSC Adv., 2015, 5, 7773
    DOI: 10.1039/C4RA11374H

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