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Issue 4, 2015
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Gadolinium nicotinate clusters as potential MRI contrast agents

Xinping Lin,a  Qiongqiong Zhang,a  Jiahe Chen,d  Xiangjian Kong,c  La-Sheng Long,c  Cheng Wangb  and  Wenbin Lin*ab 
Author affiliations

* Corresponding authors

a Collaborative Innovation Center of Chemistry for Energy Materials, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, P. R. China
E-mail: wenbinlin@uchicago.edu

b Department of Chemistry, University of Chicago, 929 E 57th Street, Chicago, USA

c State Key Laboratory of Physical Chemistry of Solid Surfaces, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China

d Department of Physics and Electronic Science, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, China

Abstract

Three multinuclear gadolinium(III) clusters containing the nicotinate (nic) ligand, [Gd2(nic)6(H2O)4] (1), [Gd4(μ3-OH)4(Hnic)5(H2O)12](ClO4)8·7H2O (2), and [Gd4(μ3-OH)4(nic)6(H2O)6]2(ClO4)4·4H2O (3) were synthesized and characterized. Potential applications of these Gd(III) clusters as high-field magnetic resonance imaging (MRI) contrast agents were evaluated. The longitudinal relaxivities (r1) of 1–3 in water at 7 T were determined to be 10.45 ± 0.16, 9.28 ± 0.06, and 2.04 ± 0.29 mM−1 s−1 on a per Gd ion basis, respectively. In 1% agarose solution, the r1 values increased slightly to 10.37 ± 0.31, 10.74 ± 0.11, and 4.60 ± 0.29 mM−1 s−1 for 1–3, respectively. The ability to tune the number of inner-sphere water molecules, cluster sizes, organic ligands, and Gd coordination modes in such Gd(III) clusters provide interesting opportunities to further enhance the MR relaxivities for potential MRI applications.

Graphical abstract: Gadolinium nicotinate clusters as potential MRI contrast agents

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Publication details

The article was received on 01 Aug 2014, accepted on 28 Nov 2014 and first published on 28 Nov 2014


Article type: Paper
DOI: 10.1039/C4RA07853E
Author version available: Download Author version (PDF)
Citation: RSC Adv., 2015,5, 2914-2919
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    Gadolinium nicotinate clusters as potential MRI contrast agents

    X. Lin, Q. Zhang, J. Chen, X. Kong, L. Long, C. Wang and W. Lin, RSC Adv., 2015, 5, 2914
    DOI: 10.1039/C4RA07853E

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