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Issue 9, 2015
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Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

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Abstract

A facile method for introducing one or more deuterium atoms onto an aromatic nucleus via Br/D exchange with high functional group tolerance and high incorporation efficiency is disclosed. Deuterium-labeled aryl chlorides and aryl borates which could be used as substrates in cross-coupling reactions to construct more complicated deuterium-labeled compounds can also be synthesized by this method.

Graphical abstract: Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

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Publication details

The article was received on 06 Jun 2015, accepted on 07 Jul 2015 and first published on 13 Jul 2015


Article type: Research Article
DOI: 10.1039/C5QO00181A
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2015,2, 1071-1075
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    Palladium-catalyzed Br/D exchange of arenes: selective deuterium incorporation with versatile functional group tolerance and high efficiency

    H. Zhang, P. V. Bonnesen and K. Hong, Org. Chem. Front., 2015, 2, 1071
    DOI: 10.1039/C5QO00181A

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