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Issue 6, 2015
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The Mitsunobu reaction in the 21st century

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The Mitsunobu reaction was first described almost fifty years ago and has enjoyed immense popularity since its inception. The purpose of this review is to focus on the more recent advances and applications of Mitsunobu chemistry, particularly from the 1990s to the present day. In addition to a discussion of newer reagents that facilitate purification, we will describe more contemporary applications of this chemistry, especially as applied to the synthesis of pharmaceuticals and their precursors.

Graphical abstract: The Mitsunobu reaction in the 21st century

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The article was received on 13 Jan 2015, accepted on 12 Mar 2015 and first published on 17 Mar 2015

Article type: Review Article
DOI: 10.1039/C5QO00016E
Author version available: Download Author version (PDF)
Citation: Org. Chem. Front., 2015,2, 739-752
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    The Mitsunobu reaction in the 21st century

    S. Fletcher, Org. Chem. Front., 2015, 2, 739
    DOI: 10.1039/C5QO00016E

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