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Issue 11, 2015
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Nanoscale detection of metal-labeled copolymers in patchy polymersomes

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Abstract

We report the synthesis of polymersome-forming block copolymers using two different synthetic routes based on Atom Transfer Radical Polymerization (ATRP) and Reversible Addition Fragmentation chain Transfer (RAFT) polymerization, respectively. Functionalization with 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) allowed the block copolymer chains to be labelled with electron-dense metal ions (e.g. indium). The resulting metal-conjugated copolymers can be visualized by transmission electron microscopy with single chain resolution, hence enabling the study of polymer/polymer immiscibility and phase separation on the nano-scale.

Graphical abstract: Nanoscale detection of metal-labeled copolymers in patchy polymersomes

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Publication details

The article was received on 05 Nov 2014, accepted on 02 Jan 2015 and first published on 05 Jan 2015


Article type: Paper
DOI: 10.1039/C4PY01508H
Author version available: Download Author version (PDF)
Citation: Polym. Chem., 2015,6, 2065-2068
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    Nanoscale detection of metal-labeled copolymers in patchy polymersomes

    L. Ruiz-Pérez, J. Madsen, E. Themistou, J. Gaitzsch, L. Messager, S. P. Armes and G. Battaglia, Polym. Chem., 2015, 6, 2065
    DOI: 10.1039/C4PY01508H

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