Jump to main content
Jump to site search

Issue 4, 2015
Previous Article Next Article

A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

Author affiliations

Abstract

2-{2-(Methacryloyloxy)ethyldimethylammonium}ethyl n-butyl phosphate (MBP) was synthesized and polymerized by controlled free radical methods to afford a new set of “reverse zwitterionic” choline phosphate (CP) substituted polymers. The synthesis overcomes prior limitations associated with related CP-methacrylates, affording facile access to MBP homopolymers and MBP-containing diblock copolymers. Dynamic light scattering revealed the size of polyMBP in water, while cell culture assays showed polyMBP to have excellent biocompatibility and non-immunogenicity. The facile synthesis of MBP monomer, and the corresponding polymers, opens a new platform towards a diverse set of functional, hydrophilic biocompatible polymers.

Graphical abstract: A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

Back to tab navigation

Supplementary files

Publication details

The article was received on 19 Sep 2014, accepted on 20 Oct 2014 and first published on 07 Nov 2014


Article type: Communication
DOI: 10.1039/C4PY01292E
Citation: Polym. Chem., 2015,6, 525-530
  •   Request permissions

    A facile approach to hydrophilic, reverse zwitterionic, choline phosphate polymers

    G. Hu, S. S. Parelkar and T. Emrick, Polym. Chem., 2015, 6, 525
    DOI: 10.1039/C4PY01292E

Search articles by author

Spotlight

Advertisements