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Issue 23, 2015
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Cell-targeted platinum nanoparticles and nanoparticle clusters

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Abstract

Herein, we report the facile preparation of cell-targeted platinum nanoparticles (PtNPs), through the design of peptides that, as a single molecule added in small concentration during the synthesis, control the size of PtNP clusters during their growth, stabilise the PtNPs in aqueous suspension and enable the functionalisation of the PtNPs with a versatile range of cell-targeting ligands. Water-soluble PtNPs targeted respectively at blood group antigens and at integrin receptors are demonstrated.

Graphical abstract: Cell-targeted platinum nanoparticles and nanoparticle clusters

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Publication details

The article was received on 24 Apr 2015, accepted on 08 May 2015 and first published on 08 May 2015


Article type: Paper
DOI: 10.1039/C5OB00822K
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Citation: Org. Biomol. Chem., 2015,13, 6567-6572
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    Cell-targeted platinum nanoparticles and nanoparticle clusters

    S. Papst, M. A. Brimble, C. W. Evans, D. J. Verdon, V. Feisst, P. R. Dunbar, R. D. Tilley and D. E. Williams, Org. Biomol. Chem., 2015, 13, 6567
    DOI: 10.1039/C5OB00822K

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