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Issue 13, 2015
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Development of a flow method for the hydroboration/oxidation of olefins

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Abstract

A method for the continuous preparation of alcohols by hydroboration/oxidation of olefins using flow techniques is described. The process allows the isolation of up to 120 mmol h−1 of the desired alcohol in a very rapid manner with good functional group tolerance. The flow setup can be modified to perform a continuous extraction of the desired alcohol from the biphasic mixture produced by the reaction.

Graphical abstract: Development of a flow method for the hydroboration/oxidation of olefins

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Publication details

The article was received on 28 Jan 2015, accepted on 12 Feb 2015 and first published on 17 Feb 2015


Article type: Communication
DOI: 10.1039/C5OB00170F
Citation: Org. Biomol. Chem., 2015,13, 3871-3877
  • Open access: Creative Commons BY license
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    Development of a flow method for the hydroboration/oxidation of olefins

    J. A. Souto, R. A. Stockman and S. V. Ley, Org. Biomol. Chem., 2015, 13, 3871
    DOI: 10.1039/C5OB00170F

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