Issue 44, 2015
From the journal:

Organic & Biomolecular Chemistry

A diphenyl ether derived bidentate secondary phosphine oxide as a preligand for nickel-catalyzed C–S cross-coupling reactions†

Nadeesha P. N. Wellalaa  and  Hairong Guan*a  

* Corresponding authors

a Department of Chemistry, University of Cincinnati, P.O. Box 210172, Cincinnati, Ohio 45221-0172, USA
E-mail: hairong.guan@uc.edu
Fax: (+1)513-556-9239
Tel: (+1)513-556-6377

Abstract

A new bidentate secondary phosphine oxide (SPO) was synthesized from diphenyl ether via ortho-lithiation, phosphorylation with PhP(Cl)NEt2, and hydrolysis in an acidic medium. Nickel(0) species ligated with this new SPO was established as a more effective catalyst than Ni(0)–Ph2P(O)H for the cross-coupling of aryl iodides with aryl thiols.

Graphical abstract: A diphenyl ether derived bidentate secondary phosphine oxide as a preligand for nickel-catalyzed C–S cross-coupling reactions

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Article information

DOI
https://doi.org/10.1039/C5OB01874A
Article type
Communication
Submitted
09 Sep 2015
Accepted
06 Oct 2015
First published
06 Oct 2015

Org. Biomol. Chem., 2015,13, 10802-10807

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A diphenyl ether derived bidentate secondary phosphine oxide as a preligand for nickel-catalyzed C–S cross-coupling reactions

N. P. N. Wellala and H. Guan, Org. Biomol. Chem., 2015, 13, 10802 DOI: 10.1039/C5OB01874A

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