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Issue 42, 2015
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A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

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Abstract

N-Protected amino acids can be easily converted into chiral α-amino aldehydes in a one-pot reaction by activation with CDI followed by reduction with DIBAL-H. This method delivers Boc-, Cbz- and Fmoc-protected amino aldehydes from proteinogenic amino acids in very good isolated yields and complete stereointegrity.

Graphical abstract: A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

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Publication details

The article was received on 02 Sep 2015, accepted on 25 Sep 2015 and first published on 25 Sep 2015


Article type: Communication
DOI: 10.1039/C5OB01838B
Citation: Org. Biomol. Chem., 2015,13, 10456-10460
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    A rapid and efficient one-pot method for the reduction of N-protected α-amino acids to chiral α-amino aldehydes using CDI/DIBAL-H

    J. Ivkovic, C. Lembacher-Fadum and R. Breinbauer, Org. Biomol. Chem., 2015, 13, 10456
    DOI: 10.1039/C5OB01838B

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