Issue 42, 2015

The development of a short route to the API ropinirole hydrochloride

Abstract

A four-step, three-stage synthesis of the API ropinirole hydrochloride has been developed from a commercially available naphthalene derivative. The new route has half the step-count and twice the overall yield of the current manufacturing process. Key features of the synthesis are a regioselective Birch reduction and an ozonolysis with concomitant ring closure to induce the required ring contraction.

Graphical abstract: The development of a short route to the API ropinirole hydrochloride

Supplementary files

Article information

Article type
Paper
Submitted
19 Aug 2015
Accepted
28 Aug 2015
First published
28 Aug 2015

Org. Biomol. Chem., 2015,13, 10532-10539

Author version available

The development of a short route to the API ropinirole hydrochloride

Z. Yousuf, A. K. Richards, A. N. Dwyer, B. Linclau and D. C. Harrowven, Org. Biomol. Chem., 2015, 13, 10532 DOI: 10.1039/C5OB01739D

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