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Issue 41, 2015
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Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy

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Abstract

The jadomycins are a family of secondary metabolites produced by S. venezuelae ISP5230. Specific jadomycins have been shown to possess a variety of anticancer, antifungal, and antibacterial properties, with different molecular mechanisms of action. Herein we demonstrate qualitative and quantitative direct binding between the validated anticancer target human topoisomerase IIβ and jadomycin DS using WaterLOGSY NMR spectroscopy. Additionally, we report for the first time, that jadomycin DS also binds a variety of other proteins, likely in a non-specific manner. Such interactions may rationalize the potential polypharmacology of jadomycin DS.

Graphical abstract: Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy

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Publication details

The article was received on 22 Jul 2015, accepted on 18 Aug 2015 and first published on 18 Aug 2015


Article type: Paper
DOI: 10.1039/C5OB01508A
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 10324-10327
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    Investigations into the binding of jadomycin DS to human topoisomerase IIβ by WaterLOGSY NMR spectroscopy

    C. F. Martinez-Farina, N. McCormick, A. W. Robertson, H. Clement, A. Jee, A. Ampaw, N. Chan, R. T. Syvitski and D. L. Jakeman, Org. Biomol. Chem., 2015, 13, 10324
    DOI: 10.1039/C5OB01508A

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