Issue 34, 2015

One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes

Abstract

A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor–acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.

Graphical abstract: One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes

Supplementary files

Article information

Article type
Communication
Submitted
16 Jul 2015
Accepted
29 Jul 2015
First published
30 Jul 2015

Org. Biomol. Chem., 2015,13, 8993-8995

One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes

V. A. Maslivetc, M. Rubina and M. Rubin, Org. Biomol. Chem., 2015, 13, 8993 DOI: 10.1039/C5OB01462J

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