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Issue 34, 2015
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A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines

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Abstract

In this paper we describe the use of a chiral aldehyde derived from lactate esters for determining the enantiopurity of primary amines, via the formation of diastereomeric imines. The method was shown to be suitable for reproducibly determining the enantiopurity of a diverse set of chiral amines. Both enantiomers of the aldehyde can be prepared in two steps from commercially available materials.

Graphical abstract: A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines

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Publication details

The article was received on 09 Jul 2015, accepted on 21 Jul 2015 and first published on 29 Jul 2015


Article type: Paper
DOI: 10.1039/C5OB01398D
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Citation: Org. Biomol. Chem., 2015,13, 9050-9054
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    A lactate-derived chiral aldehyde for determining the enantiopurity of enantioenriched primary amines

    S. M. Gibson, R. M. Lanigan, L. Benhamou, A. E. Aliev and T. D. Sheppard, Org. Biomol. Chem., 2015, 13, 9050
    DOI: 10.1039/C5OB01398D

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