Issue 30, 2015
From the journal:

Organic & Biomolecular Chemistry

De novo synthesis of phenolic dihydroxanthene near-infrared emitting fluorophores†

Jean-Alexandre Richard*a  

* Corresponding authors

a Organic Chemistry, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block, #03-08, Singapore 138667, Singapore
E-mail: jean_alexandre@ices.a-star.edu.sg

Abstract

We report a flexible de novo synthesis of phenolic dihydroxanthene fluorophores. The synthesis relies on a one-pot formation of an aldehyde intermediate which can be diversified in 60–70% overall yield, providing an efficient access to this family of near-infrared emitting fluorophores.

Graphical abstract: De novo synthesis of phenolic dihydroxanthene near-infrared emitting fluorophores

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Article information

DOI
https://doi.org/10.1039/C5OB01223F
Article type
Communication
Submitted
16 Jun 2015
Accepted
29 Jun 2015
First published
06 Jul 2015

Org. Biomol. Chem., 2015,13, 8169-8172

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De novo synthesis of phenolic dihydroxanthene near-infrared emitting fluorophores

J. Richard, Org. Biomol. Chem., 2015, 13, 8169 DOI: 10.1039/C5OB01223F

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