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Issue 29, 2015
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Synthetic applications of hypophosphite derivatives in reduction

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Abstract

The development of new tools for the reduction of organic functions to reach high chemo- and stereo-selectivity is an important research domain. Although, aluminum and boron hydrides are commonly used, they suffer from environmentally and safety issues. In particular, at industrial scale, the search for more specific and efficient reagents with a lower ecological impact remains one of the main objectives of organic chemists. This review captures highlights from literature concerning phosphonic and phosphinic acid derivatives as reducing agents and evaluates their potential as alternatives, in particular to boron and aluminum hydrides.

Graphical abstract: Synthetic applications of hypophosphite derivatives in reduction

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Publication details

The article was received on 22 May 2015, accepted on 02 Jun 2015 and first published on 02 Jun 2015


Article type: Review Article
DOI: 10.1039/C5OB01032B
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Citation: Org. Biomol. Chem., 2015,13, 7879-7906
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    Synthetic applications of hypophosphite derivatives in reduction

    C. Guyon, E. Métay, F. Popowycz and M. Lemaire, Org. Biomol. Chem., 2015, 13, 7879
    DOI: 10.1039/C5OB01032B

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