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Issue 25, 2015
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An update on new methods to synthesize cyclotetrapeptides

Luis M. De Leon Rodriguez,a  Andreas J. Weidkampa  and  Margaret A. Brimble*ab 
Author affiliations

* Corresponding authors

a Maurice Wilkins Centre for Molecular Biodiscovery, The University of Auckland, Auckland, New Zealand

b School of Chemical Sciences, The University of Auckland, Auckland, New Zealand
E-mail: m.brimble@auckland.ac.nz

Abstract

Cyclotetrapeptides are important bioactive lead drug molecules that display a wide spectrum of pharmacological activities. However, the synthesis of cyclotetrapeptides from their linear precursors is challenging due to the highly constrained conformation required for cyclisation, thus hampering their progress to a clinical setting. This review provides an account of the reported methods used for the synthesis of cyclotetrapeptides.

Graphical abstract: An update on new methods to synthesize cyclotetrapeptides

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Publication details

The article was received on 01 May 2015, accepted on 21 May 2015 and first published on 21 May 2015


Article type: Review Article
DOI: 10.1039/C5OB00880H
Author version available: Download Author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 6906-6921
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    An update on new methods to synthesize cyclotetrapeptides

    L. M. De Leon Rodriguez, A. J. Weidkamp and M. A. Brimble, Org. Biomol. Chem., 2015, 13, 6906
    DOI: 10.1039/C5OB00880H

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