Jump to main content
Jump to site search

Issue 25, 2015
Previous Article Next Article

Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst

Author affiliations

Abstract

A one-pot two-step reaction (Knoevenagel condensation – reduction of the double bond) has been developed using calcium hydride as a reductant in the presence of a supported noble metal catalyst. The reaction between carbonyl compounds and active methylene compounds such as methylcyanoacetate, 1,3-dimethylbarbituric acid, dimedone and the more challenging dimethylmalonate, affords the corresponding monoalkylated products in moderate to good yields (up to 83%) with minimal reduction of the starting carbonyl compounds.

Graphical abstract: Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst

Back to tab navigation

Supplementary files

Publication details

The article was received on 27 Apr 2015, accepted on 29 May 2015 and first published on 29 May 2015


Article type: Paper
DOI: 10.1039/C5OB00849B
Author version
available:
Download author version (PDF)
Citation: Org. Biomol. Chem., 2015,13, 7067-7075
  •   Request permissions

    Reductive alkylation of active methylene compounds with carbonyl derivatives, calcium hydride and a heterogeneous catalyst

    C. Guyon, M. Duclos, M. Sutter, E. Métay and M. Lemaire, Org. Biomol. Chem., 2015, 13, 7067
    DOI: 10.1039/C5OB00849B

Search articles by author

Spotlight

Advertisements